Choline is nutrient similar to the B vitamins. It can be made in the liver. It is also found in foods such as meats, fish, nuts, beans, vegetables, and eggs.

Choline is most commonly used for liver disease. It is also used for memory, mental function, preventing certain birth defects, and many other conditions, but there is not good scientific evidence to support many of these uses.

How it works

Choline is similar to a B vitamin. It is used in many chemical reactions in the body. Choline seems to be important in the nervous system and for development of normal brain functioning. In asthma, choline might help decrease swelling and inflammation.


Likely Effective
Fatty liver disease

People who receive nutrition through the vein can develop choline deficiency. Low blood levels of choline can cause fat to accumulate in the liver. Giving choline intravenously (by IV) helps treat this condition.


Likely safe

Choline is LIKELY SAFE for most adults when taken by mouth or when given intravenously (by IV) in appropriate amounts

Possibly unsafe

Taking high doses of choline by mouth is POSSIBLY UNSAFE for adults due to the increased risk of side effects. Doses up to 3.5 grams for adults over 18 years of age are not likely to cause unwanted side effects. Doses over 3.5 grams daily are more likely to cause side effects such as sweating, a fishy body odor, diarrhea, and vomiting.



Children: Choline isLIKELY SAFEfor most children when taken by mouth in appropriate amounts. Taking high doses of choline by mouth isPOSSIBLY UNSAFEdue to the increased risk of side effects. Doses up to 1gramdaily for children 1-8 years of age, 2 grams daily for children 9-13, and 3 grams daily for children 14-18, are not likely to cause unwanted side effects.Are there any interactions with medications?

Pregnancy and breast-feeding: Choline is LIKELY SAFE when taken by mouth and used appropriately during pregnancy and breast-feeding. Doses up to 3 grams daily for pregnant and breast-feeding women up to 18 years of age, and 3.5 grams daily for women 19 years and older are not likely to cause unwanted side effects. There isn't enough information available about the safety of choline used in higher doses in pregnant or lactating women. It's best to stick to recommended doses.

Loss of bladder control: Taking choline in doses of 9 grams daily or more might worsen this condition.


Always consult with your doctor.

Taking choline with atropine might decrease the effectiveness of atropine.

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