Gamma linolenic acid is a fatty substance found in various plant seed oils such as borage oil and evening primrose oil. People use it as medicine.
Gamma linolenic acid (GLA) is used for conditions that affect the skin including systemic sclerosis, psoriasis, and eczema. It is also used for rheumatoid arthritis (RA), polyps in the mouth, high cholesterol and other blood fats, heart disease, metabolic syndrome (Syndrome-X), diabetic nerve pain, attention deficit-hyperactivity disorder (ADHD), depression, depression after childbirth, chronic fatigue syndrome (CFS), and hay fever (allergic rhinitis). Some people use it to prevent cancer and to help breast cancer patients respond faster to treatment with the drug tamoxifen.
How it works
Gamma linolenic acid is an omega-6 fatty acid, which the body can convert to substances that reduce inflammation and cell growth.
Possibly EffectiveNerve problems due to diabetes (diabetic neuropathy)
Taking gamma linolenic acid by mouth for 6-12 months seems to reduce symptoms and prevent nerve damage in people with nerve pain due to type 1 or type 2 diabetes. Gamma linolenic acid seems to work better in people with good blood sugar control.
Gamma linolenic acid is POSSIBLY SAFE for most adults when taken by mouth in amounts of no more than 2.8 grams per day for up to a year. It can cause digestive-tract side effects, such as soft stools, diarrhea, belching, and intestinal gas. It can also make blood take longer to clot.
Pregnancy and breast-feeding: There is not enough reliable information about the safety of taking gamma linolenic acid if you arepregnantor breast-feeding . Stay on the safe side and avoid use.
Bleeding disorders: Gamma linolenic acid might slow blood clotting. There is some concern that it might increase the risk of bruising and bleeding in people with bleeding disorders.
Surgery: Since gamma linolenic acid might slow blood clotting, there is concern that it might increase the risk of extra bleeding during and after surgery. Stop taking gamma linolenic acid at least 2 weeks before a scheduled surgery.
Gamma linolenic acid might slow blood clotting. Taking gamma linolenic acid along with medications that also slow clotting might increase the chances of bruising and bleeding.Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), diclofenac (Voltaren, Cataflam, others), ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naprosyn, others), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, warfarin (Coumadin), and others.Taking gamma linolenic acid with phenothiazines might increase the risk of having a seizure in some people.Some phenothiazines include chlorpromazine (Thorazine), fluphenazine (Prolixin), trifluoperazine (Stelazine), thioridazine (Mellaril), and others.