Glycomacropeptide is a type of short protein. It is formed from a milk protein during the process of making cheese. Unlike most other proteins, glycomacropeptide contains very little of the amino acid phenylalanine.

People take glycomacropeptide for heart disease, preventing dental cavities, gout, infant development, liver disease, phenylketonuria, mental conditions, and weight loss.

How it works

Glycomacropeptide might help improve weight loss by increasing the release of chemicals that make people feel full. Glycomacropeptide might also attach to certain bacteria, viruses, and toxins and prevent them from infecting people.


Not Proven

Early research suggests that replacing a typical phenylalanine-free diet with foods enriched in glycomacropeptide maintains blood levels of the amino acid phenylalanine and does not negatively affect health and kidney function in people with phenylketonuria. But compared to a typical phenylalanine-free diet, people with phenylketonuria prefer to eat foods enriched in glycomacropeptide.

Weight loss

Clinical research suggests that replacing one or two meals daily with a meal-replacement supplement containing glycomacropeptide for one year while also following an energy restricted diet reduces weight by approximately 24 lbs compared to baseline. However, the effect of the glycomacropeptide supplement does not appear to be different than taking a similar skim milk powder supplement.

Heart disease
Dental cavities
Infant development
Liver disease
Mental conditions
Other conditions


Possibly safe

Glycomacropeptide is POSSIBLY SAFE when taken by mouth as a food supplement for up to one year.



Pregnancy and breast-feeding: Not enough is known about the use of glycomacropeptide duringpregnancyandbreast-feeding. Stay on the safe side and avoid use.Dosing considerations for Glycomacropeptide.

Children: Glycomacropeptide is POSSIBLY SAFE when added to formula and given to infants. However, there is some concern that formula containing glycomacropeptide might increase the risk of blood threonine levels becoming too high (hyperthreoninemia).


No information available.

The information provided on this page is for reference purposes and is not meant to be used as a medical advice, diagnosis or treatment. Always consult with a medical professional.