Grape

18/Description

About

Grapes are the fruit of a vine (Vitis vinifera). The whole fruit, skin, leaves and seed of the grape plant are used as medicine. Grape seeds are by-products of the manufacturing of wine. Be careful not to confuse grape with grapefruit, and other similar sounding medicines.

Grape is used for preventing diseases of the heart and blood vessels, varicose veins, hemorrhoids, “hardening of the arteries” (atherosclerosis), high blood pressure, swelling after injury or surgery, heart attack, and stroke.

Some people also use grape as a mild laxative for constipation. You have probably heard of grape “fasts” as part of “detoxification.”

Grape seed is used for diabetes complications such as nerve and eye problems, improving wound healing, preventing tooth decay, preventing cancer, an eye disease called age-related macular degeneration (AMD), poor night vision, liver disorders, and hay fever.

Dried grapes, raisins, or sultanas (white raisins) are used for cough.

Grape leaf is used for attention deficit-hyperactivity disorder (ADHD), chronic fatigue syndrome (CFS), diarrhea, heavy menstrual bleeding, uterine bleeding, and canker sores.

Grape leaf is used as a food, particularly in Greek cooking.

How it works

Grape contains flavonoids, which can have antioxidant effects, lower the levels of low density lipoproteins (LDLs, or “bad cholesterol”), relax blood vessels, and reduce the risk of coronary heart disease. The antioxidants in grape might help to prevent heart disease and have other potentially beneficial effects. Red grape varieties provide more antioxidants than white or blush grape varieties.

Grape leaf might reduce inflammation and have astringent effects. In other words, grape leaf seems to be able to draw tissue together, which could help stop bleeding and diarrhea. These properties appear to be greatest in the red leaves.

Effectiveness

Possibly Effective
Poor circulation that can cause the legs to swell (chronic venous insufficiency)

Taking grape seed extract by mouth seems to reduce symptoms of chronic venous insufficiency such as tired or heavy legs, tension, and tingling and pain. Research suggests that taking a specific grape leaf extract (AS 195, Antistax, Boehringer Ingelheim) by mouth decreases leg swelling after 6 weeks.

Eye stress

Taking grape seed extract by mouth might help decrease stress on the eyes from glare.

Concerns

Likely safe

Grape is LIKELY SAFE when consumed in amounts commonly found in foods

Possibly safe

Grape is POSSIBLY SAFE when taken by mouth in medicinal amounts. Grape seed extracts have been used safely in studies for up to 14 weeks. Eating large quantities of grapes, dried grapes, raisins, or sultanas might cause diarrhea. Some people have allergic reactions to grapes and grape products. Some other potential side effects include stomach upset, indigestion, nausea, vomiting, cough, dry mouth, sore throat, infections, headache, and muscular problems.

18/Warnings

Warnings

Pregnancy and breast-feeding: Not enough is known about the use of grape in medicinal amounts (supplements or amounts that are higher than normal food amounts) duringpregnancyand breast-feeding. Stay on the safe side and avoid use.

Bleeding conditions: Grape might slow blood clotting. Taking grape might increase the chances of bruising and bleeding in people with bleeding conditions. However, there are no reports of this occurring in humans.

Surgery: Grape might slow blood clotting. It might cause extra bleeding during and after surgery. Stop using medicinal amounts of grape at least 2 weeks before a scheduled surgery.

Interactions

Always consult with your doctor.
Moderate
Phenacetin

Some medications are changed and broken down by the liver. Grape juice might increase how quickly the liver breaks down some medications. Taking grape along with some medications that are changed by the liver can decrease the effectiveness of these medications. Before taking grape, talk to your healthcare provider if you take any medications that are changed by the liver.Some of these medications that are changed by the liver include amitriptyline (Elavil), caffeine, chlordiazepoxide (Librium), clomipramine (Anafranil), clopidogrel (Plavix), clozapine (Clozaril), cyclobenzaprine (Flexaril), desipramine (Norpramin), diazepam (Valium), estradiol (Estrace, others), flutamide (Eulexin), fluvoxamine (Luvox), grepafloxacin (Raxar), haloperidol (Haldol), imipramine (Tofranil), mexiletine (Mexitil), mirtazapine (Remeron), naproxen (Naprosyn), nortriptyline (Pamelor), olanzapine (Zyprexa), ondansetron (Zofran), propafenone (Rythmol), propranolol (Inderal), riluzole (Rilutek), ropinirole (Requip), ropivacaine (Naropin), tacrine (Cognex), theophylline (Theo-Dur, others), verapamil (Calan, Covera-HS, others), warfarin (Coumadin), and zileuton (Zyflo).Grape might slow blood clotting. Taking grape along with medications that also slow clotting might increase the chances of bruising and bleeding.Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, indomethacin (Indocin), ticlopidine (Ticlid), warfarin (Coumadin), and others.The body breaks down phenacetin to get rid of it. Drinking grape juice might increase how quickly the body breaks down phenacetin. Taking phenacetin along with grape juice might decrease the effectiveness of phenacetin.

Warfarin (Coumadin)

Warfarin (Coumadin) is used to slow blood clotting. Grape seed might also slow blood clotting. Taking grape seed along with warfarin (Coumadin) might increase the chances of bruising and bleeding. Be sure to have your blood checked regularly. The dose of your warfarin (Coumadin) might need to be changed.

Minor
Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates)

Some medications are changed and broken down by the liver. Grape seed might decrease how quickly the liver breaks down some medications. Taking grape along with some medications that are changed by the liver might increase the effects and side effects of these medications. Before taking grape, talk to your healthcare provider if you take any medications that are changed by the liver.Some of these medications that are changed by the liver include amitriptyline (Elavil), diazepam (Valium), zileuton (Zyflo), celecoxib (Celebrex), diclofenac (Voltaren), fluvastatin (Lescol), glipizide (Glucotrol), ibuprofen (Advil, Motrin), irbesartan (Avapro), losartan (Cozaar), phenytoin (Dilantin), piroxicam (Feldene), tamoxifen (Nolvadex), tolbutamide (Tolinase), torsemide (Demadex), warfarin (Coumadin), and others.Some medications are changed and broken down by the liver. Grape seed might decrease how quickly the liver breaks down some medications. Taking grape along with some medications that are changed by the liver might increase the effects and side effects of these medications. Before taking grape, talk to your healthcare provider if you take any medications that are changed by the liver.Some of these medications that are changed by the liver include lovastatin (Mevacor), ketoconazole (Nizoral), itraconazole (Sporanox), fexofenadine (Allegra), triazolam (Halcion), and numerous others. Use grape cautiously or avoid in patients taking these drugs.

The information provided on this page is for reference purposes and is not meant to be used as a medical advice, diagnosis or treatment. Always consult with a medical professional. The content on this page has been provided with thanks by RxList.com