Hesperidin

18/Description

About

Hesperidin is a plant chemical that is classified as a “bioflavonoid.” It is found primarily in citrus fruits. People use it as medicine.

Hesperidin alone, or in combination with other citrus bioflavonoids (diosmin, for example), is most often used for blood vessel conditions such as hemorrhoids, varicose veins, and poor circulation (venous stasis). It is also used to treat lymphedema, a condition involving fluid retention that can be a complication of breast cancer surgery.

How it works

Hesperidin may help blood vessels function better. It may also reduce inflammation.

Effectiveness

Possibly Effective
Poor circulation in the legs (chronic venous insufficiency, CVI)

Taking a particular product (Cyclo 3 Fort) containing hesperidin methyl chalcone, butcher's broom, and vitamin C by mouth seems to relieve the symptoms of poor circulation in the legs. Also, taking a specific product (Daflon 500, Les Laboratoires Servier) containing hesperidin and diosmin by mouth for 2-6 months seems to improve CVI symptoms, although taking the drug Venoruton might be more effective for treating this condition.

Hemorrhoids

Some research suggests that taking a specific product (Daflon 500, Les Laboratoires Servier) containing hesperidin and diosmin by mouth for up to 3 months improves symptoms of anal hemorrhoids. It may also prevent hemorrhoids from coming back after they have healed.

Leg ulcers from poor circulation (venous stasis ulcers)

Taking a specific product (Daflon 500, Les Laboratoires Servier) containing hesperidin and diosmin by mouth for 2 months seems to improve the healing of small venous stasis ulcers when used along with compression dressings.

Concerns

Possibly safe

Hesperidin is POSSIBLY SAFE for most people when taken by mouth for up to 6 months. The safety of using it for a longer period of time is unknown. Side effects include stomach pain and upset, diarrhea, and headache.

18/Warnings

Warnings

Pregnancy and breast-feeding: Hesperidin isPOSSIBLY SAFEforpregnantor breast-feeding women when taken by mouth with diosmin.

Bleeding disorder: Hesperidin might slow blood clotting and increase the risk of bleeding. In theory, hesperidin might make bleeding disorders worse.

Low blood pressure: Hesperidin might lower blood pressure. In theory, taking hesperidin might make blood pressure become too low in people who already have low blood pressure.

Surgery: Hesperidin might prolong bleeding. There is concern that hesperidin might increase the risk of bleeding during and after surgical procedures. Stop taking hesperidin at least 2 weeks before a scheduled surgery.

Interactions

Always consult with your doctor.
Moderate
Celiprolol

Hesperidin may reduce how much celiprolol the body absorbs. This might decrease how well celiprolol works. Do not take hesperidin with celiprolol.

Diltiazem

Hesperidin may reduce how much diltiazem the body absorbs. This might decrease how well diltiazem works. Do not take diltiazem with hesperidin.

Verapamil

Hesperidin might decrease blood pressure. Taking hesperidin along with medications used to lower high blood pressure might cause your blood pressure to go too low.Some medications for high blood pressure include nifedipine (Adalat, Procardia), verapamil (Calan, Isoptin, Verelan), diltiazem (Cardizem), isradipine (DynaCirc), felodipine (Plendil), amlodipine (Norvasc), and others.Some medications are moved by pumps in cells. Hesperidin might make these pumps less active and increase the amount of some medications that get absorbed by the body. This might increase the amount of some medications in the body, which could lead to more side effects. But there is not enough information to know if this is a big concern.Some medications that are moved by these pumps include etoposide, paclitaxel, vinblastine, vincristine, vindesine, ketoconazole, itraconazole, amprenavir, indinavir, nelfinavir, saquinavir, cimetidine, ranitidine, diltiazem, verapamil, corticosteroids, erythromycin, cisapride (Propulsid), fexofenadine (Allegra), cyclosporine, loperamide (Imodium), quinidine, and others.Hesperidin might slow blood clotting. Taking hesperidin along with medications that also slow clotting might increase the chances of bruising and bleeding.Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), diclofenac (Voltaren, Cataflam, others), ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naprosyn, others), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, warfarin (Coumadin), and others.Hesperidin might cause sleepiness and drowsiness. Drugs that cause sleepiness and drowsiness are called sedatives. Taking hesperidin along with sedative medications might cause too much sleepiness.Some of these sedative medications include alprazolam (Xanax), clonazepam (Klonopin), diazepam (Valium), lorazepam (Ativan), midazolam (Versed), temazepam (Restoril), triazolam (Halcion), and others.Hesperidin might cause sleepiness and drowsiness. Medications that cause sleepiness are called sedatives. Taking hesperidin along with sedative medications might cause too much sleepiness. Taking hesperidin along with sedative medications used in surgery might cause prolonged sedation.Some sedative medications include pentobarbital (Nembutal), phenobarbital (Luminal), secobarbital (Seconal), thiopental (Pentothal), fentanyl (Duragesic, Sublimaze), morphine, propofol (Diprivan), and others.Hesperidin may increase how much verapamil the body absorbs. This might increase the effects and side effects of verapamil. Do not take verapamil with hesperidin.

The information provided on this page is for reference purposes and is not meant to be used as a medical advice, diagnosis or treatment. Always consult with a medical professional.