Hyperimmune Egg



Hyperimmune egg is an egg from a hen that has been vaccinated against certain infectious diseases. The hen develops specific antibodies that rev up the immune system to fight the specific diseases included in the vaccination. These antibodies pass into the hen's eggs. People harvest the eggs and remove the antibodies. These antibodies are then used to treat diseases in people.

Hyperimmune egg is used to treat diarrhea caused by rotavirus, infectious diarrhea, osteoarthritis, rheumatoid arthritis, and high cholesterol. It is also used for general stimulation of the immune system.

How it works

Antibodies contained in hyperimmune egg are thought to stimulate the immune system and help the body fight disease.

Most of the research on hyperimmune egg comes from the manufacturer of a specific brand name product (Immune26, Legacy for Life). This and related products contain the proprietary ingredient, Egcel, which is a specific hyperimmune egg extract. According to product information, this product is produced first by repeatedly immunizing hens with at least 24 inactivated bacteria including Shigella dysenteriae, Staphylococcus epidermidis and simulans, Escherichia coli (E. coli), Salmonella enteritidis and typhimurium, Pseudomonas aeruginosa, Klebsiella pneumoniae, Haemophilus influenzae, and at least 6 species of Streptococcus.


Not Proven
Diarrhea caused by rotavirus (rotaviral diarrhea)

Developing research suggests that a preparation of purified antibodies from hyperimmune eggs harvested from hens immunized against strains of rotavirus can modestly decrease rotaviral diarrhea in children aged 2-24 months.


One research study found that some people with osteoarthritis feel less joint pain or swelling after taking a specific “immune egg” powder formulation (Immune26, Legacy for Life) for 2 months. But some researchers believe this study was not well designed and the results might be questionable.

Rheumatoid arthritis

One research study found that taking a specific “immune egg” powder formulation (Immune26, Legacy for Life) for 2 months does not significantly improve rheumatoid arthritis symptoms. Poor study design significantly limits the reliability of this research.

High cholesterol

Developing research suggests that taking a specific “immune egg” powder formulation (Immune26, Legacy for Life) for 26 weeks does not significantly lower cholesterol.

Infectious diarrhea
Other conditions


Hyperimmune egg seems to be safe for adults when used appropriately up to 26 weeks. Some people may experience diarrhea, gas, and bloating.



Children: A non-commercial purified hyperimmune egg extract has been safely used in children aged 2-24 months in a research study lasting 4 days. But, it is not known if commercially available hyperimmune egg products marketed as dietary supplements are safe for children.Dosing considerations for Hyperimmune Egg.

Pregnancy and breast-feeding: Not enough is known about the use of hyperimmune egg during pregnancy and breast-feeding. Stay on the safe side and avoid use.

Egg allergy: Hyperimmune egg is made from chicken eggs. There is some concern that people who are allergic to chicken eggs might also be allergic to hyperimmune egg products.


No information available.

The information provided on this page is for reference purposes and is not meant to be used as a medical advice, diagnosis or treatment. Always consult with a medical professional.