Resveratrol

Supplements

18/Description

About

Resveratrol is a chemical found in red wine, red grape skins, purple grape juice, mulberries, and in smaller amounts in peanuts. It is used as a medicine.

People use resveratrol for "hardening of the arteries" (atherosclerosis), lowering "bad" (LDL) cholesterol levels, increasing "good" (HDL) cholesterol levels, and preventing cancer and heart disease. It is also used for symptoms of a lung disorder "chronic obstructive pulmonary disease" and to improve the health of the liver in people with liver damage not caused by drinking alcohol. Resveratrol is used to improve glucose levels in the blood in people with diabetes, to reduce body fat in people with a condition called metabolic syndrome, and to slow signs of aging in the skin.

Some people apply resveratrol to their skin to treat acne.

Resveratrol is used as a nasal spray for symptoms of seasonal allergies (hay fever).

How it works

Resveratrol might expand blood vessels and reduce the activity of cells important in blood clotting. Some research suggests that resveratrol has weak estrogen (a female hormone) effects. It may also decrease pain and swelling (inflammation). Resveratrol might reduce levels of sugar (glucose) in the blood and help the body fight against disease. It might also prevent proteins in the brain from sticking together to help prevent diseases such as Alzheimer's disease.

Effectiveness

Possibly Effective
Diabetes

Taking 250-1000 mg of resveratrol daily for up to 3 months appears to help control blood sugar levels and improve how well insulin works in people with type 2 diabetes. Lower doses of 5 mg twice daily for 4 weeks might also improve how well insulin works. Resveratrol does not seem to affect blood sugar levels or how well insulin works in people without diabetes.

Concerns

Likely safe

Resveratrol is LIKELY SAFEwhen used in the amounts found in foods

Possibly safe

Resveratrol is POSSIBLY SAFEwhen applied to the skin for up to 30 days or when taken by mouth in doses up to 1500 mg daily for up to 3 months. Higher doses of up to 3000 mg have been taken by mouth safely for up to 8 weeks. In children, resveratrol is POSSIBLY SAFEwhen sprayed in the nostrils for up to 2 months.

18/Warnings

Warnings

Pregnancy and breast-feeding: Resveratrol isLIKELY SAFEwhen used in amounts found in some foods. However, duringpregnancyandbreast-feeding, the source of resveratrol is important. Resveratrol is found in grape skins, grape juice, wine, and otherfoodsources. Wine should not be used as a source of resveratrol during pregnancy and breast-feeding.

Bleeding disorders: Resveratrol might slow blood clotting and increase the risk of bleeding in people with bleeding disorders.

Hormone-sensitive condition such as breast cancer, uterine cancer, ovarian cancer, endometriosis, or uterine fibroids: Resveratrol might act like estrogen. If you have any condition that might be made worse by exposure to estrogen, don"t use resveratrol.

Surgery: Resveratrol might increase the risk of bleeding during and after surgery. Stop using resveratrol at least 2 weeks before a scheduled surgery.

Interactions

Always consult with your doctor.
Moderate
Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs)

Some medications are changed and broken down by the liver. Resveratrol might decrease how quickly the liver breaks down some medications. In theory, taking resveratrol along with some medications that are broken down by the liver may increase the effects and side effects of some medications.Some medications changed by the liver include chlorzoxazone, theophylline, and bufuralol.Some medications are changed and broken down by the liver. Resveratrol might decrease how quickly the liver breaks down some medications. In theory, taking resveratrol along with some medications that are broken down by the liver may increase the effects and side effects of some medications.Some medications changed by the liver include clozapine (Clozaril), cyclobenzaprine (Flexeril), fluvoxamine (Luvox), haloperidol (Haldol), imipramine (Tofranil), mexiletine (Mexitil), olanzapine (Zyprexa), pentazocine (Talwin), propranolol (Inderal), tacrine (Cognex), zileuton (Zyflo), zolmitriptan (Zomig), and others.Some medications are changed and broken down by the liver. Resveratrol might decrease how quickly the liver breaks down some medications. In theory, taking resveratrol along with some medications that are broken down by the liver may increase the effects and side effects of some medications.Some medications changed by the liver include theophylline, omeprazole, clozapine, progesterone, lansoprazole, flutamide, oxaliplatin, erlotinib, and caffeine.Some medications are changed and broken down by the liver. Resveratrol might decrease how quickly the liver breaks down some medications. In theory, taking resveratrol along with some medications that are broken down by the liver may increase the effects and side effects of some medications.Some medications changed by the liver include amitriptyline (Elavil), carisoprodol (Soma), citalopram (Celexa), diazepam (Valium), lansoprazole (Prevacid), omeprazole (Prilosec), phenytoin (Dilantin), warfarin, and many others.Some medications are changed and broken down by the liver. Resveratrol might decrease how quickly the liver breaks down some medications. In theory, taking resveratrol along with some medications that are broken down by the liver may increase the effects and side effects of some medications.Some medications changed by the liver include acetaminophen, chlorzoxazone (Parafon Forte), ethanol, theophylline, and anesthetics such as enflurane (Ethrane), halothane (Fluothane), isoflurane (Forane), methoxyflurane (Penthrane).Some medications are changed and broken down by the liver. Resveratrol might decrease how quickly the liver breaks down some medications. In theory, taking resveratrol along with some medications that are broken down by the liver may increase the effects and side effects of some medications. However, some early research shows conflicting results.Some medications changed by the liver include some calcium channel blockers (diltiazem, nicardipine, verapamil), chemotherapeutic agents (etoposide, paclitaxel, vinblastine, vincristine, vindesine), antifungals (ketoconazole, itraconazole), glucocorticoids, alfentanil (Alfenta), cisapride (Propulsid), fentanyl (Sublimaze), lidocaine (Xylocaine), losartan (Cozaar), fexofenadine (Allegra), midazolam (Versed), and otherslovastatin (Mevacor), ketoconazole (Nizoral), itraconazole (Sporanox), fexofenadine (Allegra), triazolam (Halcion), and many others.Resveratrol might slow blood clotting. Taking resveratrol along with medications that also slow clotting might increase the chances of bruising and bleeding.Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), diclofenac (Voltaren, Cataflam, others), ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naprosyn, others), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, warfarin (Coumadin), and others.

The information provided on this page is for reference purposes and is not meant to be used as a medical advice, diagnosis or treatment. Always consult with a medical professional.