Squalamine is a chemical produced from the stomach and the liver of the spiny dogfish shark. Squalamine can also be made in the laboratory.

People take squalamine as an antibiotic to fight bacterial infections.

The lab-made version of squalamine is sometimes applied directly to the skin as an antibiotic.

Some researchers are studying squalamine to see if it might be effective against solid tumors in children. Other researchers are studying squalamine in combination with a prescription high blood pressure medication called captopril. They want to see if this combination is a good treatment for eye disease caused by diabetes.

Don't confuse squalamine with shark cartilage, which is prepared from the cartilage of spiny dogfish shark, hammerhead shark (Sphyrna lewini), and other shark species.

How it works

Squalamine is thought to prevent growth of bacteria that cause infections. It also contains chemicals that seem to prevent the formation and growth of tumors.


Not Proven
Eye conditions in people with diabetes
Infections, when taken by mouth or applied to the skin
Other conditions


It is not known if squalamine is safe or what the possible side effects might be.



Pregnancy and breast-feeding: Not enough is known about the use of squalamine duringpregnancyandbreast-feeding. Stay on the safe side and avoid use.Dosing considerations for Squalamine.


No information available.

The information provided on this page is for reference purposes and is not meant to be used as a medical advice, diagnosis or treatment. Always consult with a medical professional.