White Pepper

18/Description

About

White pepper grows in tropical Asian countries. Black pepper and white pepper both come from the same plant. But they are prepared differently. Black pepper is made by cooking the dried unripe fruit. White pepper is made by cooking and drying the ripe seeds.

People take white pepper by mouth for upset stomach, malaria, a bacterial infection that causes diarrhea (cholera), and cancer.

People apply white pepper to the skin to reduce pain.

White pepper is added to foods and drinks to add flavor.

White pepper essential oil is used in aromatherapy.

How it works

White pepper contains a chemical called piperine. This chemical seems to have many effects in the body. It seems to reduce pain, improve breathing, and reduce inflammation. Piperine also seems to improve brain function, but it is not clear how.

Effectiveness

Not Proven
Cancer
A bacterial infection that causes diarrhea (cholera)
Malaria
Pain
Upset stomach
Other conditions

Concerns

Likely safe

White pepper is LIKELY SAFE when taken by mouth in amounts commonly found in foods

Possibly safe

White pepper is POSSIBLY SAFE when taken by mouth appropriately as medicine. White pepper might have a burning aftertaste. Taking large amounts of white pepper by mouth, which can accidentally get into the lungs, has been reported to cause death. This is especially true in children.

18/Warnings

Warnings

Pregnancy: White pepper isLIKELY SAFEwhen taken by mouth in amounts commonly found in foods. There isn't enough reliable information available to know if taking white pepper as medicine or applying white pepper oil to the skin is safe whilepregnant.

Breast-feeding: White pepper is LIKELY SAFE when taken by mouth in amounts commonly found in foods. There isn't enough reliable information available to know if taking white pepper as medicine is safe while breast-feeding.

Children: White pepper is LIKELY SAFE when taken by mouth in amounts commonly found in foods. It is POSSIBLY UNSAFE when taken by mouth in large amounts.

Bleeding conditions: Piperine, a chemical in white pepper, might slow blood clotting. In theory, taking white pepper in amounts greater than those in food might increase the risk of bleeding in people with bleeding disorders.

Diabetes: White pepper might affect blood sugar levels. In theory, taking white pepper in amounts greater than those in food might affect blood sugar control in people with diabetes. Dosing adjustments for diabetes medications might be needed.

Surgery: Piperine, a chemical in white pepper, might slow blood clotting and affect blood sugar levels. In theory, white pepper might cause bleeding complications or affect blood sugar levels during surgery. You should stop taking white pepper in amounts greater than those in food at least 2 weeks before surgery.

Interactions

Always consult with your doctor.
Moderate
Cyclosporine

White pepper contains a chemical called piperine. Piperine might increase levels of cyclosporine in the body. In theory, taking white pepper with cyclosporine might increase the effects and side effects of cyclosporine.

Lithium

White pepper might have an effect like a water pill or "diuretic." Taking white pepper might decrease how well the body gets rid of lithium. This could increase how much lithium is in the body and result in serious side effects. Talk with your healthcare provider before using this product if you are taking lithium. Your lithium dose might need to be changed.

Nevirapine

Some medications are changed and broken down by the liver. White pepper might decrease how quickly the liver breaks down some medications. Taking white pepper along with some medications that are broken down by the liver might increase the chance of side effects from some medications. Before taking white pepper, talk to your healthcare provider if you are taking any medications that are changed by the liver.Some medications changed by the liver include chlorzoxazone, theophylline, and bufuralol.Some medications are changed and broken down by the liver. White pepper might decrease how quickly the liver breaks down some medications. Taking white pepper along with some medications that are broken down by the liver might increase the chance of side effects from some medications. Before taking white pepper, talk to your healthcare provider if you are taking any medications that are changed by the liver.Some medications changed by the liver include cyclophosphamide, ifosfamide, barbiturates, bromobenzene, and others.Some medications are changed and broken down by the liver. White pepper might decrease how quickly the liver breaks down some medications. Taking white pepper along with some medications that are broken down by the liver might increase the chance of side effects from some medications. Before taking white pepper, talk to your healthcare provider if you are taking any medications that are changed by the liver.Some medications changed by the liver include amitriptyline (Elavil), codeine, desipramine (Norpramin), flecainide (Tambocor), haloperidol (Haldol), imipramine (Tofranil), metoprolol (Lopressor, Toprol XL), ondansetron (Zofran), paroxetine (Paxil), risperidone (Risperdal), tramadol (Ultram), venlafaxine (Effexor), and others.Some medications are changed and broken down by the liver. White pepper might decrease how quickly the liver breaks down some medications. Taking white pepper along with some medications that are broken down by the liver might increase the chance of side effects from some medications. Before taking white pepper, talk to your healthcare provider if you are taking any medications that are changed by the liver.Some medications changed by the liver include some calcium channel blockers (diltiazem, nicardipine, verapamil), chemotherapeutic agents (etoposide, paclitaxel, vinblastine, vincristine, vindesine), antifungals (ketoconazole, itraconazole), glucocorticoids, cisapride (Propulsid), alfentanil (Alfenta), fentanyl (Sublimaze), losartan (Cozaar), fluoxetine (Prozac), midazolam (Versed), omeprazole (Prilosec), ondansetron (Zofran), propranolol (Inderal), fexofenadine (Allegra), and many others.White pepper contains a chemical called piperine. Some research shows that piperine might decrease blood sugar levels. In theory, white pepper might cause an interaction with diabetes medications resulting in blood sugar levels going too low. Until more is known, monitor your blood sugar closely if you take white pepper. The dose of your diabetes medication might need to be changed.Some medications used for diabetes include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), and others.Some medications are moved by pumps in cells. White pepper might make these pumps less active and increase how much of some medications get absorbed by the body. In theory, this might cause more side effects from some medications.Some medications that are moved by these pumps include etoposide, paclitaxel, vinblastine, vincristine, vindesine, ketoconazole, itraconazole, amprenavir, indinavir, nelfinavir, saquinavir, cimetidine, ranitidine, diltiazem, verapamil, digoxin, corticosteroids, erythromycin, cisapride (Propulsid), fexofenadine (Allegra), cyclosporine, loperamide (Imodium), quinidine, and others.White pepper contains a chemical called piperine. Piperine might slow blood clotting. In theory, taking white pepper along with medications that also slow clotting might increase the chances of bruising and bleeding.Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, ticlopidine (Ticlid), warfarin (Coumadin), and others.White pepper contains a chemical called piperine. Piperine might increase levels of nevirapine in the body. In theory, taking white pepper with nevirapine might increase the effects and side effects of nevirapine. However, there is not enough known about this potential interaction to know if it is a big concern.

Pentobarbital (Nembutal)

White pepper contains a chemical called piperine. Piperine might increase sleepiness caused by pentobarbital. In theory, taking white pepper with pentobarbital might increase the sedative side effects of pentobarbital.

Phenytoin (Dilantin)

White pepper might increase how much phenytoin (Dilantin) the body absorbs. Taking white pepper along with phenytoin (Dilantin) might increase the effects and side effects of phenytoin (Dilantin).

Propranolol (Inderal)

White pepper might increase how much propranolol (Inderal) the body absorbs. Taking white pepper along with propranolol (Inderal) might increase the effects and side effects of propranolol (Inderal).

Rifampin

White pepper might increase how much rifampin the body absorbs. Taking white pepper along with rifampin might increase the effects and side effects of rifampin.

Theophylline

White pepper can increase how much theophylline the body can absorb. This might cause increased effects and side effects of theophylline.

Minor
Amoxicillin (Amoxil, Trimox)

White pepper contains a chemical called piperine. Piperine might increase levels of amoxicillin in the blood. In theory, taking white pepper with amoxicillin might increase the effects and side effects of amoxicillin. However, there is not enough known about this potential interaction to know if it is a big concern.

Carbamazepine (Tegretol)

White pepper might increase the amount of carbamazepine (Tegretol) absorbed by the body. It might also decrease how quickly the body breaks down and gets rid of carbamazepine. This could increase how much carbamazepine is in the body and potentially increase the chance of side effects. However, there is not enough known about this potential interaction to know if it is a big concern.

Cefotaxime (Claforan)

White pepper contains a chemical called piperine. Piperine might increase levels of cefotaxime in the blood. In theory, taking white pepper with cefotaxime might increase the effects and side effects of cefotaxime. However, there is not enough known about this potential interaction to know if it is a big concern.

The information provided on this page is for reference purposes and is not meant to be used as a medical advice, diagnosis or treatment. Always consult with a medical professional.